OpenSky Research Reports

Electronic Vaccination Registry Research:  How vaccination data systems shape coverage, across 65 countries and territories.

Since 2021, OpenSky Data Systems has worked with MSD on a research programme mapping Electronic Vaccination Registries (EVRs) across Europe and Latin America. Using HPV vaccination as a case study, the research examines how registries record, connect and report vaccination data, and how that affects the Vaccine Coverage Rates (VCRs).

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Our Research Approach

OpenSky’s Research Projects Division leads this programme, led by Prof. Tudor Pitulac. Each study combines desk research, structured scorecards and interviews with immunisation specialists and national agencies. Findings are cross-checked across sources before conclusions are drawn. 

A consistent method across regions

Every report scores registries on the same criteria, including governance, architecture, interoperability and how often data is published. This lets organisations compare systems within a region and see how registry maturity relates to coverage.

Grounded in International standards

Our gold standard for EVR architecture is built on HL7 FHIR, the standard used by the WHO for its vaccination card work. We consulted HL7, EVR technology specialists and national immunisation offices to develop it. 

Developed in Partnership

This research is a long-term collaboration with MSD. OpenSky also works with CeADAR (Ireland’s National Centre for Applied AI), The Alan Turing Institute and the Global Health Connector Partnership. 

Shared with the Immunisation Community

We’ve presented findings at the I-HD conference in Ghent and the Adult Immunisation Board in Antwerp as well as presenting a cross-regional analysis covering Europe, Asia Pacific and Latin America at the IPVS conference.

From Research to Real-World Uptake

The research shows where vaccination data systems fall short. OpenSky Uptake Intelligence, our AI-driven insight engine, turns that data into action. In a joint project with MSD and the Ministry of Health Slovakia, it uncovered the drivers and barriers to HPV vaccination and guided targeted interventions that led to a 40% increase in coverage.